Prognostic value of tumour blood flow, [F-18]EF5 and [F-18]FDG PET/CT imaging in patients with head and neck cancer treated with radiochemotherapy - UTU Research Portal

A1 Refereed original research article in a scientific journal

Prognostic value of tumour blood flow, [F-18]EF5 and [F-18]FDG PET/CT imaging in patients with head and neck cancer treated with radiochemotherapy

Authors: Komar G, Lehtio K, Seppanen M, Eskola O, Levola H, Lindholm P, Sipila H, Seppala J, Grenman R, Solin O, Minn H

Publisher: SPRINGER

Publication year: 2014

Journal: European Journal of Nuclear Medicine and Molecular Imaging

Journal name in source: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Journal acronym: EUR J NUCL MED MOL I

Volume: 41

Issue: 11

First page : 2042

Last page: 2050

Number of pages: 9

ISSN: 1619-7070

DOI: https://doi.org/10.1007/s00259-014-2818-3

Abstract

Conclusion Our study in a limited number of patients confirmed the importance of MATV in the prognosis of locally advanced squamous cell carcinoma of the head and neck. It is of interest that high uptake of the hypoxia tracer [F-18]EF5 showed a stronger correlation with a poor clinical outcome than [F-18]FDG uptake. This confirms the importance of hypoxia in treatment outcome and suggests that [F-18]EF5 may act as a surrogate marker of radioresistance.