Oral treatment with a vitamin D3 analogue (BXL628) has anti-inflammatory effects in rodent model of interstitial cystitis

: Benigni F, Baroni E, Zecevic M, Zvara P, Streng T, Hedlund P, Colli E, D'Ambrosio D, Andersson KE

Publisher: BLACKWELL PUBLISHING

: 2006

BJU International

BJU INTERNATIONAL

: BJU INT

: 97

: 3

: 617

: 624

: 8

: 1464-4096

DOI: https://doi.org/10.1111/j.1464-410X.2006.05971.x

Vitamin D3 analogues may successfully be used as anti-inflammatory agents in allergen-mediated inflammatory reactions. Moreover, the modulatory effect shown on mast cell activation by the BXL628 analogue strongly supports its potential therapeutic use in a possibly mast cell-dependent disease such as human interstitial cystitis.