Transient Receptor Potential A1 (TRPA1) Activity in the Human Urethra-Evidence for a Functional Role for TRPA1 in the Outflow Region



: Gratzke C, Streng T, Waldkirch E, Sigl K, Stief C, Andersson KE, Hedlund P

Publisher: ELSEVIER SCIENCE BV

: 2009

European Urology

EUROPEAN UROLOGY

: EUR UROL

: 55

: 3

: 696

: 704

: 9

: 0302-2838

DOI: https://doi.org/10.1016/j.eururo.2008.04.042


Conclusions: The localization of TRPA1 to nerves that also express TRPV1 and CGRP, and in urothelial cells and interstitial cells, as well as the findings that TRPA1 agonists can modify tone of urethral preparations, propose a role for TRPA1 in afferent and efferent sensory signaling of the human outflow region. (C) 2008 European Association of Urology. Published by Elsevier B.V. All rights reserved



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