A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
TRPA1 Receptor Induced Relaxation of the Human Urethra Involves TRPV1 and Cannabinoid Receptor Mediated Signals, and Cyclooxygenase Activation
Tekijät: Weinhold P, Gratzke C, Streng T, Stief C, Andersson KE, Hedlund P
Kustantaja: ELSEVIER SCIENCE INC
Julkaisuvuosi: 2010
Journal: Journal of Urology
Tietokannassa oleva lehden nimi: JOURNAL OF UROLOGY
Lehden akronyymi: J UROLOGY
Numero sarjassa: 5
Vuosikerta: 183
Numero: 5
Aloitussivu: 2070
Lopetussivu: 2076
Sivujen määrä: 7
ISSN: 0022-5347
DOI: https://doi.org/10.1016/j.juro.2009.12.093
Tiivistelmä
Conclusions: Relaxation to TRPA1 agonists in human urethral preparations seem to work in cooperation with TRPV1 mediated signals, are negatively coupled via cannabinoid receptor activation and involve cyclooxygenase products. Urothelial TRPA1 signals may not be important to regulate normal human urethral smooth muscle tone. This does not exclude a role in the initiation of afferent activity normally and in disease states.
Conclusions: Relaxation to TRPA1 agonists in human urethral preparations seem to work in cooperation with TRPV1 mediated signals, are negatively coupled via cannabinoid receptor activation and involve cyclooxygenase products. Urothelial TRPA1 signals may not be important to regulate normal human urethral smooth muscle tone. This does not exclude a role in the initiation of afferent activity normally and in disease states.
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