A1 Refereed original research article in a scientific journal
TRPA1 Receptor Induced Relaxation of the Human Urethra Involves TRPV1 and Cannabinoid Receptor Mediated Signals, and Cyclooxygenase Activation
Authors: Weinhold P, Gratzke C, Streng T, Stief C, Andersson KE, Hedlund P
Publisher: ELSEVIER SCIENCE INC
Publication year: 2010
Journal: Journal of Urology
Journal name in source: JOURNAL OF UROLOGY
Journal acronym: J UROLOGY
Number in series: 5
Volume: 183
Issue: 5
First page : 2070
Last page: 2076
Number of pages: 7
ISSN: 0022-5347
DOI: https://doi.org/10.1016/j.juro.2009.12.093(external)
Abstract
Conclusions: Relaxation to TRPA1 agonists in human urethral preparations seem to work in cooperation with TRPV1 mediated signals, are negatively coupled via cannabinoid receptor activation and involve cyclooxygenase products. Urothelial TRPA1 signals may not be important to regulate normal human urethral smooth muscle tone. This does not exclude a role in the initiation of afferent activity normally and in disease states.
Conclusions: Relaxation to TRPA1 agonists in human urethral preparations seem to work in cooperation with TRPV1 mediated signals, are negatively coupled via cannabinoid receptor activation and involve cyclooxygenase products. Urothelial TRPA1 signals may not be important to regulate normal human urethral smooth muscle tone. This does not exclude a role in the initiation of afferent activity normally and in disease states.
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