A1 Refereed original research article in a scientific journal

TRPA1 Receptor Induced Relaxation of the Human Urethra Involves TRPV1 and Cannabinoid Receptor Mediated Signals, and Cyclooxygenase Activation




AuthorsWeinhold P, Gratzke C, Streng T, Stief C, Andersson KE, Hedlund P

PublisherELSEVIER SCIENCE INC

Publication year2010

JournalJournal of Urology

Journal name in sourceJOURNAL OF UROLOGY

Journal acronymJ UROLOGY

Number in series5

Volume183

Issue5

First page 2070

Last page2076

Number of pages7

ISSN0022-5347

DOIhttps://doi.org/10.1016/j.juro.2009.12.093(external)


Abstract
Conclusions: Relaxation to TRPA1 agonists in human urethral preparations seem to work in cooperation with TRPV1 mediated signals, are negatively coupled via cannabinoid receptor activation and involve cyclooxygenase products. Urothelial TRPA1 signals may not be important to regulate normal human urethral smooth muscle tone. This does not exclude a role in the initiation of afferent activity normally and in disease states.



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