Refereed journal article or data article (A1)

Associations between the aetiology of preterm birth and mortality and neurodevelopment up to 11 years

List of AuthorsGrönroos Linda, Rautava Päivi, Setänen Sirkku, Nyman Anna, Ekholm Eeva, Lehtonen Liisa, Ylijoki Milla; PIPARI Study Grp

PublisherWiley-Blackwell Publishing Ltd.

Publication year2023

JournalActa Paediatrica

Journal name in sourceACTA PAEDIATRICA





Self-archived copy’s web address


Aim: To investigate how the aetiology of very preterm birth/very low birth weight is associated with mortality and later neurodevelopmental outcomes.

Methods: Very preterm/very low-birth weight singletons were categorised based on the aetiology of preterm birth: spontaneous preterm birth (n = 47, 28.1%), preterm premature rupture of membranes (n = 56, 33.5%) or placental vascular pathology (n = 64, 38.3%). Mortality, cerebral palsy, severe cognitive impairment by 11 years of age (<2SD) and mean full-scale intelligence quotient at 11 years were studied in association with birth aetiology.

Results: There was no difference in mortality or rate of cerebral palsy according to birth aetiologies. The rate of severe cognitive impairment was lower (4.9% vs. 15.3%) in the preterm premature rupture of the membrane group in comparison to the placental vascular pathology group (OR 0.2, 95% CI 0.03-0.9, adjusted for gestational age). At 11 years, there was no statistically significant difference in the mean full-scale intelligence quotient.

Conclusion: Placental vascular pathology, as the aetiology of very preterm birth/very low birth weight, is associated with a higher rate of severe cognitive impairments in comparison to preterm premature rupture of membranes, although there was no difference in the mean full-scale intelligence quotient at 11 years. The aetiology of very preterm birth/very low birth weight was not associated with mortality or the rate of cerebral palsy.

Keywords: PPROM; cognitive outcome; neurodevelopment; pre-eclampsia; very preterm birth.

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Last updated on 2023-01-12 at 10:36