A2 Refereed review article in a scientific journal
Intermediate filaments in the heart: The dynamic duo of desmin and lamins orchestrates mechanical force transmission
Authors: West Gun, Sedighi Sogol, Agnetti Giulio, Taimen Pekka
Publication year: 2023
Journal: Current Opinion in Cell Biology
Journal name in source: Current opinion in cell biology
Journal acronym: Curr Opin Cell Biol
Volume: 85
ISSN: 0955-0674
eISSN: 1879-0410
DOI: https://doi.org/10.1016/j.ceb.2023.102280
Web address : https://doi.org/10.1016/j.ceb.2023.102280
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/181773404
The intermediate filament (IF) cytoskeleton supports cellular structural integrity, particularly in response to mechanical stress. The most abundant IF proteins in mature cardiomyocytes are desmin and lamins. The desmin network tethers the contractile apparatus and organelles to the nuclear envelope and the sarcolemma, while lamins, as components of the nuclear lamina, provide structural stability to the nucleus and the genome. Mutations in desmin or A-type lamins typically result in cardiomyopathies and recent studies emphasized the synergistic roles of desmin and lamins in the maintenance of nuclear integrity in cardiac myocytes. Here we explore the emerging roles of the interdependent relationship between desmin and lamins in providing resilience to nuclear structure while transducing extracellular mechanical cues into the nucleus.
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