A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä
The molecular biophysics of extracellular vimentin and its role in pathogen-host interactions
Tekijät: Parvanian Sepideh, Coelho-Rato Leila S., Eriksson John E., Patteson Alison E.
Kustantaja: CURRENT BIOLOGY LTD
Julkaisuvuosi: 2023
Journal: Current Opinion in Cell Biology
Tietokannassa oleva lehden nimi: CURRENT OPINION IN CELL BIOLOGY
Lehden akronyymi: CURR OPIN CELL BIOL
Artikkelin numero: 102233
Vuosikerta: 85
Sivujen määrä: 8
ISSN: 0955-0674
eISSN: 1879-0410
DOI: https://doi.org/10.1016/j.ceb.2023.102233
Verkko-osoite: https://www.sciencedirect.com/science/article/pii/S0955067423000820?via%3Dihub
Tiivistelmä
Vimentin, an intermediate filament protein typically located in the cytoplasm of mesenchymal cells, can also be secreted as an extracellular protein. The organization of extracellular vimentin strongly determines its functions in physiological and pathological conditions, making it a promising target for future therapeutic interventions. The extracellular form of vimentin has been found to play a role in the interaction between host cells and pathogens. In this review, we first discuss the molecular biophysics of extracellular vimentin, including its structure, secretion, and adhesion properties. We then provide a general overview of the role of extracellular vimentin in mediating pathogen-host interactions, with a focus on its interactions with viruses and bacteria. We also discuss the implications of these findings for the development of new therapeutic strategies for combating infectious diseases.
Vimentin, an intermediate filament protein typically located in the cytoplasm of mesenchymal cells, can also be secreted as an extracellular protein. The organization of extracellular vimentin strongly determines its functions in physiological and pathological conditions, making it a promising target for future therapeutic interventions. The extracellular form of vimentin has been found to play a role in the interaction between host cells and pathogens. In this review, we first discuss the molecular biophysics of extracellular vimentin, including its structure, secretion, and adhesion properties. We then provide a general overview of the role of extracellular vimentin in mediating pathogen-host interactions, with a focus on its interactions with viruses and bacteria. We also discuss the implications of these findings for the development of new therapeutic strategies for combating infectious diseases.
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