A2 Refereed review article in a scientific journal
Lectins as potential tools for cancer biomarker discovery from extracellular vesicles
Authors: Islam Md Khirul, Khan Misba, Gidwani Kamlesh, Witwer W Witwer, Lamminmäki Urpo, Leivo Janne
Publisher: BMC
Publication year: 2023
Journal: Biomarker research
Journal name in source: BIOMARKER RESEARCH
Journal acronym: BIOMARK RES
Article number: 85
Volume: 11
Number of pages: 22
eISSN: 2050-7771
DOI: https://doi.org/10.1186/s40364-023-00520-6
Web address : https://doi.org/10.1186/s40364-023-00520-6
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/181422382
Extracellular vesicles (EVs) have considerable potential as diagnostic, prognostic, and therapeutic agents, in large part because molecular patterns on the EV surface betray the cell of origin and may also be used to "target" EVs to specific cells. Cancer is associated with alterations to cellular and EV glycosylation patterns, and the surface of EVs is enriched with glycan moieties. Glycoconjugates of EVs play versatile roles in cancer including modulating immune response, affecting tumor cell behavior and site of metastasis and as such, paving the way for the development of innovative diagnostic tools and novel therapies. Entities that recognize specific glycans, such as lectins, may thus be powerful tools to discover and detect novel cancer biomarkers. Indeed, the past decade has seen a constant increase in the number of published articles on lectin-based strategies for the detection of EV glycans. This review explores the roles of EV glycosylation in cancer and cancer-related applications. Furthermore, this review summarizes the potential of lectins and lectin-based methods for screening, targeting, separation, and possible identification of improved biomarkers from the surface of EVs.
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