A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Ellagitannins from jabuticaba (Myrciaria jaboticaba) seeds attenuated inflammation, oxidative stress, aberrant crypt foci, and modulated gut microbiota in rats with 1,2 dimethyl hydrazine-induced colon carcinogenesis
Tekijät: do Carmo MAV, Fidelis M, de Oliveira PF, Feitoza LQ, Marques MJ, Ferreira EB, Oh WY, Shahidi F, Hellstrom J, Almeida LA, Novaes RD, Granato D, Azevedo L
Julkaisuvuosi: 2021
Lehti: Food and Chemical Toxicology
Tietokannassa oleva lehden nimi: FOOD AND CHEMICAL TOXICOLOGY
Lehden akronyymi: FOOD CHEM TOXICOL
Artikkelin numero: 112287
Vuosikerta: 154
Sivujen määrä: 12
ISSN: 0278-6915
DOI: https://doi.org/10.1016/j.fct.2021.112287
Julkaisun avoimuus kirjaamishetkellä: Avoimesti saatavilla
Julkaisukanavan avoimuus : Osittain avoin julkaisukanava
Since dietary factors are thought to be responsible for high colon cancer risk, we investigated the chemopreventive effect of jabuticaba seed extract (LJE) by administering yogurt with or without LJE against 1,2 dimethyl hydrazine (DMH)-induced colon carcinogenesis in rats. Results showed that LJE contained a total phenolic content of 57.16 g/100 g of seed extract in which 7.67 and 10.09 g/100 g represented total flavonoids and ellagitannins, respectively. LJE protected DNA and human LDL against induced in vitro oxidation, which was associated with the ellagitannin content and with the free-radical scavenging and reducing capacities. LJE alone had a non-clastogenicity/aneugenicity property, but in combination with cisplatin, it enhanced the chromosome aberrations in cancer cells. In colon cancer-induced rats, yogurt with or without LJE caused a reduction in proinflammatory parameters, decreased the RNA expression of antiapoptotic cytokines and increased the expression of proapoptotic cytokines. Moreover, LJE attenuated colon cancer initiation and progression by decreasing aberrant crypt foci and LJE recovered the gut microbiome. Together, this evidence suggests that LJE provides chemopreventive protection against colon cancer development by reducing inflammation and increasing proapoptotic pathways.
