Ellagitannins from jabuticaba (Myrciaria jaboticaba) seeds attenuated inflammation, oxidative stress, aberrant crypt foci, and modulated gut microbiota in rats with 1,2 dimethyl hydrazine-induced colon carcinogenesis - UTU Research Portal

A1 Refereed original research article in a scientific journal

Ellagitannins from jabuticaba (Myrciaria jaboticaba) seeds attenuated inflammation, oxidative stress, aberrant crypt foci, and modulated gut microbiota in rats with 1,2 dimethyl hydrazine-induced colon carcinogenesis

Authors: do Carmo MAV, Fidelis M, de Oliveira PF, Feitoza LQ, Marques MJ, Ferreira EB, Oh WY, Shahidi F, Hellstrom J, Almeida LA, Novaes RD, Granato D, Azevedo L

Publisher: PERGAMON-ELSEVIER SCIENCE LTD

Publication year: 2021

Journal: Food and Chemical Toxicology

Journal name in source: FOOD AND CHEMICAL TOXICOLOGY

Journal acronym: FOOD CHEM TOXICOL

Article number: 112287

Volume: 154

Number of pages: 12

ISSN: 0278-6915

DOI: https://doi.org/10.1016/j.fct.2021.112287

Publication's open availability at the time of reporting: Open Access

Publication channel's open availability : Partially Open Access publication channel

Abstract

Since dietary factors are thought to be responsible for high colon cancer risk, we investigated the chemopreventive effect of jabuticaba seed extract (LJE) by administering yogurt with or without LJE against 1,2 dimethyl hydrazine (DMH)-induced colon carcinogenesis in rats. Results showed that LJE contained a total phenolic content of 57.16 g/100 g of seed extract in which 7.67 and 10.09 g/100 g represented total flavonoids and ellagitannins, respectively. LJE protected DNA and human LDL against induced in vitro oxidation, which was associated with the ellagitannin content and with the free-radical scavenging and reducing capacities. LJE alone had a non-clastogenicity/aneugenicity property, but in combination with cisplatin, it enhanced the chromosome aberrations in cancer cells. In colon cancer-induced rats, yogurt with or without LJE caused a reduction in proinflammatory parameters, decreased the RNA expression of antiapoptotic cytokines and increased the expression of proapoptotic cytokines. Moreover, LJE attenuated colon cancer initiation and progression by decreasing aberrant crypt foci and LJE recovered the gut microbiome. Together, this evidence suggests that LJE provides chemopreventive protection against colon cancer development by reducing inflammation and increasing proapoptotic pathways.