A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Endogenous Opioid Release After Orgasm in Man: A Combined PET/Functional MRI Study
Tekijät: Jern Patrick, Chen Jinglu, Tuisku Jouni, Saanijoki Tiina, Hirvonen Jussi, Lukkarinen Lasse, Manninen Sandra, Helin Semi, Putkinen Vesa, Nummenmaa Lauri
Kustantaja: Society of Nuclear Medicine Inc.
Julkaisuvuosi: 2023
Journal: Journal of Nuclear Medicine
Tietokannassa oleva lehden nimi: Journal of Nuclear Medicine
Vuosikerta: 64
Numero: 8
Aloitussivu: 1310
Lopetussivu: 1313
DOI: https://doi.org/10.2967/jnumed.123.265512
Verkko-osoite: https://doi.org/10.2967/jnumed.123.265512
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/180906074
The endogenous m-opioid receptor (MOR) system plays a key role in the mammalian reward circuit. Human and animal experiments suggest the involvement of MORs in human sexual pleasure, yet this hypothesis currently lacks in vivo support.
Methods: We used PET with the radioligand [11C]carfentanil, which has high affinity for MORs, to quantify endogenous opioid release after orgasm in man. Participants were scanned once immediately after orgasm and once in a baseline state. Hemodynamic activity was measured with functional MRI during penile stimulation.
Results: The PET data revealed significant opioid release in the hippocampus. Hemodynamic activity in the somatosensory and motor cortices and in the hippocampus and thalamus increased during penile stimulation, and thalamic activation was linearly dependent on self-reported sexual arousal.
Conclusion: Our data show that endogenous opioidergic activation in the medial temporal lobe is centrally involved in sexual arousal, and this circuit may be implicated in orgasmic disorders.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
