A1 Refereed original research article in a scientific journal
HLA-G Alleles Impact the Perinatal Father-Child HPV Transmission
Authors: Suominen Nelli T, Roger Michel, Faucher Marie-Claude, Syrjänen Kari J, Grenman Seija E, Syrjänen Stina M, Louvanto Karolina
Publisher: MDPI
Publication year: 2023
Journal: Current Issues in Molecular Biology
Journal name in source: CURRENT ISSUES IN MOLECULAR BIOLOGY
Journal acronym: CURR ISSUES MOL BIOL
Volume: 45
Issue: 7
First page : 5798
Last page: 5810
Number of pages: 13
ISSN: 1467-3037
DOI: https://doi.org/10.3390/cimb45070366
Web address : https://doi.org/10.3390/cimb45070366
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/180852324
The host factors that influence father-to-child human papillomavirus (HPV) transmission remain unknown. This study evaluated whether human leukocyte antigen (HLA)-G alleles are important in father-to-child HPV transmission during the perinatal period. Altogether, 134 father-newborn pairs from the Finnish Family HPV Study were included. Oral, semen and urethral samples from the fathers were collected before the delivery, and oral samples were collected from their offspring at delivery and postpartum on day 3 and during 1-, 2- and 6-month follow-up visits. HLA-G alleles were tested by direct sequencing. Unconditional logistic regression was used to determine the association of the father-child HLA-G allele and genotype concordance with the father-child HPV prevalence and concordance at birth and during follow-up. HLA-G allele G*01:01:03 concordance was associated with the father's urethral and child's oral high-risk (HR)-HPV concordance at birth (OR 17.00, 95% CI: 1.24-232.22). HLA-G allele G*01:04:01 concordance increased the father's oral and child's postpartum oral any- and HR-HPV concordance with an OR value of 7.50 (95% CI: 1.47-38.16) and OR value of 7.78 (95% CI: 1.38-43.85), respectively. There was no association between different HLA-G genotypes and HPV concordance among the father-child pairs at birth or postpartum. To conclude, the HLA-G allele concordance appears to impact the HPV transmission between the father and his offspring.
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