A2 Refereed review article in a scientific journal
Renal Perfusion, Oxygenation and Metabolism: The Role of Imaging
Authors: Päivärinta Johanna, Anastasiou Ioanna A, Koivuviita Niina, Sharma Kanishka, Nuutila Pirjo, Ferrannini Ele, Solini Anna, Rebelos Eleni
Publisher: MDPI
Publication year: 2023
Journal: Journal of Clinical Medicine
Journal name in source: JOURNAL OF CLINICAL MEDICINE
Journal acronym: J CLIN MED
Article number: 5141
Volume: 12
Issue: 15
Number of pages: 14
DOI: https://doi.org/10.3390/jcm12155141
Web address : https://doi.org/10.3390/jcm12155141
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/180801469
Thanks to technical advances in the field of medical imaging, it is now possible to study key features of renal anatomy and physiology, but so far poorly explored due to the inherent difficulties in studying both the metabolism and vasculature of the human kidney. In this narrative review, we provide an overview of recent research findings on renal perfusion, oxygenation, and substrate uptake. Most studies evaluating renal perfusion with positron emission tomography (PET) have been performed in healthy controls, and specific target populations like obese individuals or patients with renovascular disease and chronic kidney disease (CKD) have rarely been assessed. Functional magnetic resonance (fMRI) has also been used to study renal perfusion in CKD patients, and recent studies have addressed the kidney hemodynamic effects of therapeutic agents such as glucagon-like receptor agonists (GLP-1RA) and sodium-glucose co-transporter 2 inhibitors (SGLT2-i) in an attempt to characterise the mechanisms leading to their nephroprotective effects. The few available studies on renal substrate uptake are discussed. In the near future, these imaging modalities will hopefully become widely available with researchers more acquainted with them, gaining insights into the complex renal pathophysiology in acute and chronic diseases.
Downloadable publication This is an electronic reprint of the original article. |  |
