A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä
Novel insights into autophagosome biogenesis revealed by cryo-electron tomography
Tekijät: Eskelinen Eeva-Liisa
Julkaisuvuosi: 2023
Journal: FEBS Letters
Tietokannassa oleva lehden nimi: FEBS letters
Lehden akronyymi: FEBS Lett
ISSN: 0014-5793
eISSN: 1873-3468
DOI: https://doi.org/10.1002/1873-3468.14726
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/180790896
Tiivistelmä
Autophagosome biogenesis, from the appearance of the phagophore to elongation and closure into an autophagosome, is one of the long-lasting open questions in the autophagy field. Recent studies utilising cryo-electron tomography and detailed analysis of the image data have revealed new information on the membrane dynamics of these events, including the shape and dimensions of omegasomes, phagophores and autophagosomes, and their relationships with the organelles around them. One of the important predictions from the new results is that 60-80% of the autophagosome membrane area is delivered by direct lipid transfer or lipid synthesis. Cryo-electron tomography can be expected to provide new directions for autophagy research in the near future.
Autophagosome biogenesis, from the appearance of the phagophore to elongation and closure into an autophagosome, is one of the long-lasting open questions in the autophagy field. Recent studies utilising cryo-electron tomography and detailed analysis of the image data have revealed new information on the membrane dynamics of these events, including the shape and dimensions of omegasomes, phagophores and autophagosomes, and their relationships with the organelles around them. One of the important predictions from the new results is that 60-80% of the autophagosome membrane area is delivered by direct lipid transfer or lipid synthesis. Cryo-electron tomography can be expected to provide new directions for autophagy research in the near future.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
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