A2 Refereed review article in a scientific journal
The risk of second primary cancer after nasopharyngeal cancer: a systematic review
Authors: Svärd Fanni, Omobolaji Alabi Rasheed, Leivo Ilmo, Mäkitie Antti A., Almangush Alhadi
Publisher: SPRINGER
Publication year: 2023
Journal: European Archives of Oto-Rhino-Laryngology
Journal name in source: EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
Journal acronym: EUR ARCH OTO-RHINO-L
Number of pages: 7
ISSN: 0937-4477
eISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-023-08144-0
Web address : http://dx.doi.org/10.1007%2Fs00405-023-08144-0
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/180641959
Purpose: Second primary cancers (SPCs) after nasopharyngeal cancer (NPC) are rare, but have an impact on the follow-up of this patient population. The aim of this study is to systematically review the literature to determine the prevalence and most typical sites of SPCs after NPC.
Methods: We searched the databases of PubMed, Web of Science, and Scopus for articles on SPCs after NPC. The Preferred Reporting Items for Systematic Review and Meta-Analyses guidelines were followed.
Results: This review includes data on 89 168 patients with NPC from 21 articles. The mean occurrence for SPCs was 6.6% and varied from 4.9% in endemic areas to 8.7% in non-endemic areas. The most frequent locations of SPCs were oral cavity, pharynx, nose and paranasal sinuses, esophagus and lung.
Conclusion: There is an increased risk for a SPC after NPC management, especially in non-endemic areas. However, their mean rate is lower than after other head and neck carcinomas.
Downloadable publication This is an electronic reprint of the original article. |  |
