A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Does Diffusely Infiltrating Lobular Carcinoma of the Breast Arise from Epithelial-Mesenchymal Hybrid Cells?
Tekijät: Tabár László, Bozó Renáta, Dean Peter B., Ormándi Katalin, Puchkova Olga, Oláh-Németh Orsolya, Németh István Balázs, Veréb Zoltán, Yen Ming-Fang, Chen Li-Sheng, Chen Hsiu-Hsi, Vörös András
Kustantaja: MDPI
Julkaisuvuosi: 2023
Journal: International Journal of Molecular Sciences
Tietokannassa oleva lehden nimi: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Lehden akronyymi: INT J MOL SCI
Artikkelin numero: 10752
Vuosikerta: 24
Numero: 13
Sivujen määrä: 15
ISSN: 1661-6596
eISSN: 1422-0067
DOI: https://doi.org/10.3390/ijms241310752
Verkko-osoite: https://doi.org/10.3390/ ijms241310752
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/180444136
Classic diffusely infiltrating lobular carcinoma has imaging features divergent from the breast cancers originating from the terminal ductal lobular units and from the major lactiferous ducts. Although the term "invasive lobular carcinoma" implies a site of origin within the breast lobular epithelium, we were unable to find evidence supporting this assumption. Exceptional excess of fibrous connective tissue and the unique cell architecture combined with the aberrant features at breast imaging suggest that this breast malignancy has not originated from cells lining the breast ducts and lobules. The only remaining relevant component of the fibroglandular tissue is the mesenchyme. The cells freshly isolated and cultured from diffusely infiltrating lobular carcinoma cases contained epithelial-mesenchymal hybrid cells with both epithelial and mesenchymal properties. The radiologic and histopathologic features of the tumours and expression of the mesenchymal stem cell positive markers CD73, CD90, and CD105 all suggest development in the direction of mesenchymal transition. These hybrid cells have tumour-initiating potential and have been shown to have poor prognosis and resistance to therapy targeted for malignancies of breast epithelial origin. Our work emphasizes the need for new approaches to the diagnosis and therapy of this highly fatal breast cancer subtype.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
