A1 Refereed original research article in a scientific journal
VKORC1-based resistance to anticoagulant rodenticides widespread in Finnish house mice but not in brown rats
Authors: Aivelo Tuomas, Koivisto Elina, Esther Alexandra, Koivisto Sanna, Huitu Otso
Publisher: TAYLOR & FRANCIS LTD
Publication year: 2023
Journal: International Journal of Pest Management
Journal name in source: INTERNATIONAL JOURNAL OF PEST MANAGEMENT
Journal acronym: INT J PEST MANAGE
Number of pages: 8
ISSN: 0967-0874
eISSN: 1366-5863
DOI: https://doi.org/10.1080/09670874.2023.2234324
Web address : https://doi.org/10.1080/09670874.2023.2234324
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/180384202
Anticoagulant rodenticide (AR) resistance is widespread across Europe, but its prevalence has not been previously studied in Finland. We sampled 48 house mice (Mus musculus) and 48 brown rat (Rattus norvegicus) in farms and urban locations from southern Finland and here we report the identification of Vkorc1 polymorphisms linked to AR resistance.Two thirds of mice carried Vkorc1 polymorphisms. The most common was the type Y139C (resistance to first-generation ARs, bromadiolone and difenacoum), whereas the type L128S (resistance to FGARs and bromadiolone) was much less abundant. Only two rats tested positive, both with a rare type R33P (resistance probably to warfarin). No clear patterns based on subregion, sex and urban/rural division were seen.We suggest that the type Y139C polymorphism should be taken into account when planning control actions targeting house mice in Finland. The low number of AR resistant rats found suggests a low prevalence of resistance in rats. To fully understand the state of AR resistance in Finland, additional studies on yellow-necked mouse (Apodemus flavicollis) and bank voles (Myodes glareolus) are needed.
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