A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Hepatoprotective effect of cyanidin-3-O-glucoside-lauric acid ester against H2O2-induced oxidative damage in LO2 cells
Tekijät: Zhou Ping, Pan Ying, Yang Wei, Yang Baoru, Ou Shiyi, Liu Pengzhan, Zheng Jie
Kustantaja: ELSEVIER
Julkaisuvuosi: 2023
Journal: Journal of Functional Foods
Lehden akronyymi: J FUNCT FOODS
Artikkelin numero: 105642
Vuosikerta: 107
Sivujen määrä: 8
ISSN: 1756-4646
eISSN: 2214-9414
DOI: https://doi.org/10.1016/j.jff.2023.105642
Verkko-osoite: https://www.sciencedirect.com/science/article/pii/S1756464623002426?via%3Dihub
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/180293198
Acylation of anthocyanin with fatty acid has been extensively applied for the improvement of their lipophilicity and stability. However, their functionalities are not fully investigated. This work prepared cyanidin-3-O-gluco-side-lauric acid ester (C3G-LA) and investigated its protective effect against oxidative stress in H2O2-induced human normal liver (LO2) cells. The results indicated that C3G-LA possessed notable antioxidant activity and better protective effect than its anthocyanin precursor cyanidin-3-O-glucoside (C3G). It protected the cells from H2O2-induced cell death and apoptosis by suppressing the overproduction of reactive oxygen species and malondialdehyde, restoring superoxide dismutase activity and ameliorating mitochondrial dysfunction and membrane damage. The increase in the expression levels of phosphorylated Akt, Nrf2, HO-1 and NQO1 further indicated that the antioxidant protective effect of C3G-LA involved the PI3K/Akt-mediated activation of the Nrf2-HO-1/NQO1 pathway. The findings indicated that, in addition to improve lipophilicity and stability, acylation of anthocyanin can enhance their anti-oxidative stress activity.
Ladattava julkaisu This is an electronic reprint of the original article. |