A1 Refereed original research article in a scientific journal
Cutaneous Melanoma of the Lip: A SEER Analysis of Epidemiology and Survival Outcomes With Focus on Surgery and Other Treatment Options
Authors: Viscardi Juan A, Scampa Matteo, Walz Solange N, Martineau Jerome, Di Summa Pietro G, Giordano Salvatore, Kalbermatten Daniel F, Oranges Carlo M
Publisher: INT INST ANTICANCER RESEARCH
Publication year: 2023
Journal: In Vivo
Journal name in source: IN VIVO
Journal acronym: IN VIVO
Volume: 37
Issue: 3
First page : 1164
Last page: 1172
Number of pages: 9
ISSN: 0258-851X
DOI: https://doi.org/10.21873/invivo.13191
Web address : https://doi.org/10.21873/invivo.13191
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/179887237
Background/aim: Cutaneous melanoma of the lip (LM) is a rare malignancy with a low overall survival (OS). Few studies exist in the literature to aid its diagnosis and treatment. The purpose of this study was to assess the different treatment modalities by collecting cases from a single database and to provide current information on the epidemiologic characteristics of cutaneous lip melanoma.
Patients and methods: The SEER database was searched for demographic, clinical-pathological, and therapeutic characteristics. The Kaplan-Meier model was used to analyze the overall survival (OS) of the study population, and survival curves were modelled. Univariable analysis between subgroups was carried out using the log-rank test. Surgery was further assessed with a multivariable cox regression, where the surgical procedure was adjusted for Breslow thickness.
Results: Patients aged 62.4 years on average, and 62.7% of them were males. A total of 386 melanomas of the cutaneous lip were identified. Mean OS was 155.1 months, median OS was 187 months, and 67.4% had localized disease.
Conclusion: LM has a poor prognosis with a 5-year OS of 75.2%. Surgery remains the mainstay of treatment, with less invasive surgical approaches yielding a comparable overall survival to surgery with greater margins.
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