A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Interaction Between Dietary Iron Intake and Genetically Determined Iron Overload: Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in the TEDDY Study
Tekijät: Thorsen Steffen U., Liu Xiang, Kataria Yachana, Mandrup-Poulsen Thomas, Kaur Simranjeet, Uusitalo Ulla, Virtanen Suvi M., Norris Jill M., Rewers Marian, Hagopian William, Yang Jimin, She Jin-Xiong, Akolkar Beena, Andrén Aronsson Carin, Lernmark Åke, Ziegler Anette-Gabriele, Toppari Jorma, Krischer Jeffrey, Parikh Hemang M., Ellervik Christina, Svensson Jannet; TEDDY Study Group
Julkaisuvuosi: 2023
Journal: Diabetes Care
Tietokannassa oleva lehden nimi: Diabetes care
Lehden akronyymi: Diabetes Care
Vuosikerta: 46
Numero: 5
Aloitussivu: 1014
Lopetussivu: 1018
ISSN: 0149-5992
eISSN: 1935-5548
DOI: https://doi.org/10.2337/dc22-1359
Verkko-osoite: https://diabetesjournals.org/care/article-abstract/46/5/1014/148558/Interaction-Between-Dietary-Iron-Intake-and?redirectedFrom=fulltext
OBJECTIVE
To examine whether iron intake and genetically determined iron overload interact in predisposing to the development of childhood islet autoimmunity (IA) and type 1 diabetes (T1D).
RESEARCH DESIGN AND METHODSIn The Environmental Determinants of Diabetes in the Young (TEDDY) study, 7,770 genetically high-risk children were followed from birth until the development of IA and progression to T1D. Exposures included energy-adjusted iron intake in the first 3 years of life and a genetic risk score (GRS) for increased circulating iron.
RESULTSWe found a U-shaped association between iron intake and risk of GAD antibody as the first autoantibody. In children with GRS ≥2 iron risk alleles, high iron intake was associated with an increased risk of IA, with insulin as first autoantibody (adjusted hazard ratio 1.71 [95% CI 1.14; 2.58]) compared with moderate iron intake.
CONCLUSIONSIron intake may alter the risk of IA in children with high-risk HLA haplogenotypes.
