A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Resistance Training Increases White Matter Density in Frail Elderly Women
Tekijät: Bucci Marco, Iozzo Patricia, Merisaari Harri, Huovinen Ville, Lipponen Heta, Räikkönen Katri, Parkkola Riitta, Salonen Minna, Sandboge Samuel, Eriksson Johan G, Nummenmaa Lauri, Nuutila Pirjo
Kustantaja: MDPI
Julkaisuvuosi: 2023
Journal: Journal of Clinical Medicine
Tietokannassa oleva lehden nimi: Journal of clinical medicine
Lehden akronyymi: J Clin Med
Artikkelin numero: 2684
Vuosikerta: 12
Numero: 7
ISSN: 2077-0383
DOI: https://doi.org/10.3390/jcm12072684
Verkko-osoite: https://www.mdpi.com/2077-0383/12/7/2684
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/179517320
We aimed to investigate the effects of maternal obesity on brain structure and metabolism in frail women, and their reversibility in response to exercise. We recruited 37 frail elderly women (20 offspring of lean/normal-weight mothers (OLM) and 17 offspring of obese/overweight mothers (OOM)) and nine non-frail controls to undergo magnetic resonance and diffusion tensor imaging (DTI), positron emission tomography with Fluorine-18-fluorodeoxyglucose (PET), and cognitive function tests (CERAD). Frail women were studied before and after a 4-month resistance training, and controls were studied once. White matter (WM) density (voxel-based morphometry) was higher in OLM than in OOM subjects. Exercise increased WM density in both OLM and OOM in the cerebellum in superior parietal regions in OLM and in cuneal and precuneal regions in OOM. OLM gained more WM density than OOM in response to intervention. No significant results were found from the Freesurfer analysis, nor from PET or DTI images. Exercise has an impact on brain morphology and cognition in elderly frail women.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
