A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä

Insulin resistance and body mass index are associated with TSPO PET in cognitively unimpaired elderly




TekijätEkblad Laura L, Tuisku Jouni, Koivumäki Mikko, Helin Semi, Rinne Juha O, Snellman Anniina

KustantajaSAGE PUBLICATIONS INC

Julkaisuvuosi2023

JournalJournal of Cerebral Blood Flow and Metabolism

Tietokannassa oleva lehden nimiJOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Lehden akronyymiJ CEREBR BLOOD F MET

Sivujen määrä13

ISSN0271-678X

eISSN0271-678X

DOIhttps://doi.org/10.1177/0271678X231172519

Verkko-osoitehttp://dx.doi.org/10.1177%2F0271678X231172519

Rinnakkaistallenteen osoitehttps://research.utu.fi/converis/portal/detail/Publication/179471078


Tiivistelmä

Metabolic risk factors are associated with peripheral low-grade inflammation and an increased risk for dementia. We evaluated if metabolic risk factors i.e. insulin resistance, body mass index (BMI), serum cholesterol values, or high sensitivity C-reactive protein associate with central inflammation or beta-amyloid (Aβ) accumulation in the brain, and if these associations are modulated by APOE4 gene dose. Altogether 60 cognitively unimpaired individuals (mean age 67.7 years (SD 4.7); 63% women; 21 APOE3/3, 20 APOE3/4 and 19 APOE4/4) underwent positron emission tomography with [11C]PK11195 targeting TSPO (18 kDa translocator protein) and [11C]PIB targeting fibrillar Aβ. [11C]PK11195 distribution value ratios and [11C]PIB standardized uptake values were calculated in a cortical composite region of interest typical for Aβ accumulation in Alzheimer’s disease. Associations between metabolic risk factors, [11C]PK11195, and [11C]PIB uptake were evaluated with linear models adjusted for age and sex. Higher logarithmic HOMA-IR (standardized beta 0.40, p = 0.002) and BMI (standardized beta 0.27, p = 0.048) were associated with higher TSPO availability. Voxel-wise analyses indicated that this association was mainly seen in the parietal cortex. Higher logarithmic HOMA-IR was associated with higher [11C]PIB (standardized beta 0.44, p = 0.02), but only in APOE4/4 homozygotes. BMI and HOMA-IR seem to influence TSPO availability in the brain.


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