A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Classification of Common Food Lipid Sources Regarding Healthiness Using Advanced Lipidomics: A Four-Arm Crossover Study
Tekijät: Monfort-Pires Milena, Lamichhane Santosh, Alonso Cristina, Egelandsdal Bjørg, Oresic Matej, Jordahl Vilde Overrein, Skjolsvold Oda, Perez-Ruiz Irantzu, Blanco Maria Encarnación, Skeie Siv, Martins Catia, Haug Anna
Kustantaja: MDPI
Julkaisuvuosi: 2023
Journal: International Journal of Molecular Sciences
Tietokannassa oleva lehden nimi: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Lehden akronyymi: INT J MOL SCI
Artikkelin numero: 4941
Vuosikerta: 24
Numero: 5
Sivujen määrä: 25
eISSN: 1422-0067
DOI: https://doi.org/10.3390/ijms24054941
Verkko-osoite: https://www.mdpi.com/1422-0067/24/5/4941
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/179203441
Prospective studies have failed to establish a causal relationship between animal fat intake and cardiovascular diseases in humans. Furthermore, the metabolic effects of different dietary sources remain unknown. In this four-arm crossover study, we investigated the impact of consuming cheese, beef, and pork meat on classic and new cardiovascular risk markers (obtained from lipidomics) in the context of a healthy diet. A total of 33 young healthy volunteers (23 women/10 men) were assigned to one out of four test diets in a Latin square design. Each test diet was consumed for 14 days, with a 2-week washout. Participants received a healthy diet plus Gouda- or Goutaler-type cheeses, pork, or beef meats. Before and after each diet, fasting blood samples were withdrawn. A reduction in total cholesterol and an increase in high density lipoprotein particle size were detected after all diets. Only the pork diet upregulated plasma unsaturated fatty acids and downregulated triglycerides species. Improvements in the lipoprotein profile and upregulation of circulating plasmalogen species were also observed after the pork diet. Our study suggests that, within the context of a healthy diet rich in micronutrients and fiber, the consumption of animal products, in particular pork meat, may not induce deleterious effects, and reducing the intake of animal products should not be regarded as a way of reducing cardiovascular risk in young individuals.
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