A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä

Sex differences, asymmetry, and age-related white matter development in infants and 5-year-olds as assessed with tract-based spatial statistics




TekijätKumpulainen Venla, Merisaari Harri, Silver Eero, Copeland Anni, Pulli Elmo P., Lewis John D., Saukko Ekaterina, Shulist Satu J., Saunavaara Jani, Parkkola Riitta, Lähdesmäki Tuire, Karlsson Linne, Karlsson Hasse, Tuulari Jetro J.

KustantajaWILEY

Julkaisuvuosi2023

JournalHuman Brain Mapping

Lehden akronyymiHUM BRAIN MAPP

Vuosikerta44

Numero7

Aloitussivu2712

Lopetussivu2725

Sivujen määrä14

ISSN1065-9471

eISSN1097-0193

DOIhttps://doi.org/10.1002/hbm.26238

Verkko-osoitehttps://onlinelibrary.wiley.com/doi/10.1002/hbm.26238

Rinnakkaistallenteen osoitehttps://research.utu.fi/converis/portal/detail/Publication/179189741


Tiivistelmä

The rapid white matter (WM) maturation of first years of life is followed by slower yet long-lasting development, accompanied by learning of more elaborate skills. By the age of 5 years, behavioural and cognitive differences between females and males, and functions associated with brain lateralization such as language skills are appearing. Diffusion tensor imaging (DTI) can be used to quantify fractional anisotropy (FA) within the WM and increasing values correspond to advancing brain development. To investigate the normal features of WM development during early childhood, we gathered a DTI data set of 166 healthy infants (mean 3.8 wk, range 2-5 wk; 89 males; born on gestational week 36 or later) and 144 healthy children (mean 5.4 years, range 5.1-5.8 years; 76 males). The sex differences, lateralization patterns and age-dependent changes were examined using tract-based spatial statistics (TBSS). In 5-year-olds, females showed higher FA in wide-spread regions in the posterior and the temporal WM and more so in the right hemisphere, while sex differences were not detected in infants. Gestational age showed stronger association with FA values compared to age after birth in infants. Additionally, child age at scan associated positively with FA around the age of 5 years in the body of corpus callosum, the connections of which are important especially for sensory and motor functions. Lastly, asymmetry of WM microstructure was detected already in infants, yet significant changes in lateralization pattern seem to occur during early childhood, and in 5-year-olds the pattern already resembles adult-like WM asymmetry.


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