A2 Refereed review article in a scientific journal
Mapping the lymphatic system across body scales and expertise domains: A report from the 2021 National Heart, Lung, and Blood Institute workshop at the Boston Lymphatic Symposium
Authors: Singhal Dhruv, Börner Katy, Chaikof Elliot L, Detmar Michael, Hollmén Maija, Iliff Jeffery J, Itkin Maxim, Mäkinen Taija, Oliver Guillermo, Padera Timothy P, Quardokus Ellen M, Radtke Andrea J, Suami Hiroo, Weber Griffin M, Rovira Ilsa I, Muratoglu Selen C, Galis Zorina S
Publisher: Frontiers Media SA
Publication year: 2023
Journal: Frontiers in Physiology
Journal name in source: FRONTIERS IN PHYSIOLOGY
Journal acronym: FRONT PHYSIOL
Article number: 1099403
Volume: 14
Number of pages: 12
eISSN: 1664-042X
DOI: https://doi.org/10.3389/fphys.2023.1099403
Web address : https://doi.org/10.3389/fphys.2023.1099403
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/178963141
Enhancing our understanding of lymphatic anatomy from the microscopic to the anatomical scale is essential to discern how the structure and function of the lymphatic system interacts with different tissues and organs within the body and contributes to health and disease. The knowledge of molecular aspects of the lymphatic network is fundamental to understand the mechanisms of disease progression and prevention. Recent advances in mapping components of the lymphatic system using state of the art single cell technologies, the identification of novel biomarkers, new clinical imaging efforts, and computational tools which attempt to identify connections between these diverse technologies hold the potential to catalyze new strategies to address lymphatic diseases such as lymphedema and lipedema. This manuscript summarizes current knowledge of the lymphatic system and identifies prevailing challenges and opportunities to advance the field of lymphatic research as discussed by the experts in the workshop.
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