A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Prognostic histological markers in oral tongue squamous cell carcinoma patients treated with (chemo)radiotherapy
Tekijät: Hyytiäinen Aini, Mroueh Rayan, Peltonen Johanna, Wennerstrand Pia, Mäkitie Antti, Al-Samadi Ahmed, Ventelä Sami, Salo Tuula
Kustantaja: WILEY
Julkaisuvuosi: 2023
Journal: APMIS
Tietokannassa oleva lehden nimi: APMIS
Lehden akronyymi: APMIS
Vuosikerta: 131
Numero: 4
Aloitussivu: 142
Lopetussivu: 151
Sivujen määrä: 10
ISSN: 0903-4641
DOI: https://doi.org/10.1111/apm.13298
Verkko-osoite: https://doi.org/10.1111/apm.13298
Rinnakkaistallenteen osoite: http://jultika.oulu.fi/files/nbnfi-fe2023042739178.pdf
Tiivistelmä
Treatment of oral tongue squamous cell carcinoma (OTSCC) frequently includes surgery with postoperative radiotherapy (RT) or chemoradiotherapy (CRT). Resistance to RT or CRT remains a major clinical challenge and highlights the need to identify predictive markers for it. We included 71 OTSCC patients treated with surgery combined with RT or CRT. We evaluated the association between tumor budding, tumor-stroma ratio (TSR), depth of invasion (DOI), tumor-infiltrating lymphocytes (TILs), hypoxia-inducible factor-1alpha (HIF-1alpha) expression, octamer-binding transcription factor 4 (OCT4) expression, high-endothelial venules (HEVs), and disease-free survival (DFS) using uni- and multivariate analyses. No significant association was observed between the different histological and molecular markers (TSR, DOI, TILs, HEV, HIF-1alph, OCT4) and DFS. However, an associative trend between DOI, budding, and DFS was noted. Further studies with larger cohorts are needed to explore the prognostic value of DOI and budding for OTSCC patients treated with postoperative RT or CRT.
Treatment of oral tongue squamous cell carcinoma (OTSCC) frequently includes surgery with postoperative radiotherapy (RT) or chemoradiotherapy (CRT). Resistance to RT or CRT remains a major clinical challenge and highlights the need to identify predictive markers for it. We included 71 OTSCC patients treated with surgery combined with RT or CRT. We evaluated the association between tumor budding, tumor-stroma ratio (TSR), depth of invasion (DOI), tumor-infiltrating lymphocytes (TILs), hypoxia-inducible factor-1alpha (HIF-1alpha) expression, octamer-binding transcription factor 4 (OCT4) expression, high-endothelial venules (HEVs), and disease-free survival (DFS) using uni- and multivariate analyses. No significant association was observed between the different histological and molecular markers (TSR, DOI, TILs, HEV, HIF-1alph, OCT4) and DFS. However, an associative trend between DOI, budding, and DFS was noted. Further studies with larger cohorts are needed to explore the prognostic value of DOI and budding for OTSCC patients treated with postoperative RT or CRT.
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