A1 Refereed original research article in a scientific journal

Biomimetic nanoparticles drive the mechanism understanding of shear-wave elasticity stiffness in triple negative breast cancers to predict clinical treatment




AuthorsZheng Dongdong, Zhou Jin, Qian Lang, Liu XueJiao, Chang Cai, Tang Shuang, Zhang Hongbo, Zhou Shichong

PublisherKEAI PUBLISHING LTD

Publication year2023

JournalBioactive Materials

Journal name in sourceBIOACTIVE MATERIALS

Journal acronymBIOACT MATER

Volume22

First page 567

Last page587

Number of pages21

eISSN2452-199X

DOIhttps://doi.org/10.1016/j.bioactmat.2022.10.025

Web address https://doi.org/10.1016/j.bioactmat.2022.10.025

Self-archived copy’s web addresshttps://research.utu.fi/converis/portal/detail/Publication/178702186


Abstract

In clinical practice, we noticed that triple negative breast cancer (TNBC) patients had higher shear-wave elas-ticity (SWE) stiffness than non-TNBC patients and a higher α-SMA expression was found in TNBC tissues than the non-TNBC tissues. Moreover, SWE stiffness also shows a clear correlation to neoadjuvant response efficiency. To elaborate this phenomenon, TNBC cell membrane-modified polylactide acid-glycolic acid (PLGA) nanoparticle was fabricated to specifically deliver artesunate to regulate SWE stiffness through inhibiting CAFs functional status. As tested in MDA-MB-231 and E0771 orthotopic tumor models, CAFs functional status inhibited by 231M-ARS@PLGA nanoparticles (231M-AP NPs) had reduced the SWE stiffness as well as attenuated hypoxia of tumor as tumor soil loosening agent which amplified the antitumor effects of paclitaxel and PD1 inhibitor. Single-cell sequencing indicated that the two main CAFs (extracellular matrix and wound healing CAFs) that produces extracellular matrix could influence the tumor SWE stiffness as well as the antitumor effect of drugs. Further, biomimetic nanoparticles inhibited CAFs function could attenuate tumor hypoxia by increasing proportion of inflammatory blood vessels and oxygen transport capacity. Therefore, our finding is fundamental for under-standing the role of CAFs on affecting SWE stiffness and drugs antitumor effects, which can be further implied in the potential clinical theranostic predicting in neoadjuvant therapy efficacy through non-invasive analyzing of SWE imaging.


Downloadable publication

This is an electronic reprint of the original article.
This reprint may differ from the original in pagination and typographic detail. Please cite the original version.





Last updated on 2024-26-11 at 23:32