Comparative Case Studies: Methodological DiscussionCase Study Research has a long tradition and it has been used in different areas of social sciences to approach research questions that command context sensitiveness and attention to complexity while tapping on multiple sources. Comparative Case Studies have been suggested as providing effective tools to understanding policy and practice along three different axes of social scientific research, namely horizontal (spaces), vertical (scales), and transversal (time). The chapter, first, sketches the methodological basis of case-based research in comparative studies as a point of departure, also highlighting the requirements for comparative research. Second, the chapter focuses on presenting and discussing recent developments in scholarship to provide insights on how comparative researchers, especially those investigating educational policy and practice in the context of globalization and internationalization, have suggested some critical rethinking of case study research to account more effectively for recent conceptual shifts in the social sciences related to culture, context, space and comparison. In a third section, it presents the approach to comparative case studies adopted in the European research project YOUNG_ADULLLT that has set out to research lifelong learning policies in their embeddedness in regional economies, labour markets and individual life projects of young adults. The chapter is rounded out with some summarizing and concluding remarks.