A1 Refereed original research article in a scientific journal
Synthesis, characterization and biocompatibility of guar gum-benzoic acid
Authors: Le Trung-Anh, Guo Yong, Zhou Jun-Nian, Yan Jiaqi, Zhang Hongbo, Huynh Tan-Phat
Publisher: ELSEVIER
Publication year: 2022
Journal: International Journal of Biological Macromolecules
Journal name in source: INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Journal acronym: INT J BIOL MACROMOL
Volume: 194
First page : 110
Last page: 116
Number of pages: 7
ISSN: 0141-8130
eISSN: 1879-0003
DOI: https://doi.org/10.1016/j.ijbiomac.2021.11.180
Web address : https://doi.org/10.1016/j.ijbiomac.2021.11.180
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/178553525
A novel chemical functionalization of guar gum (GG) by benzoic acid (BA) via nucleophilic substitution reaction in aqueous solution has been reported. BA moieties are chosen due to coordination chemistry of carboxylic acid moieties, hydrophobicity and intermolecular interaction of aromatic rings. The presence of conjugated BA on guar gum-benzoic acid (GG-BA) with grafting density of 5.5% is confirmed by 1H NMR. Amorphous GG-BA with irregular morphology has been studied by UV-Vis, FTIR, XRD, SEM, TEM, TGA, computational chemistry and contact angle measurement. GG-BA in a concentration range from 0 to 4000 mu g mL-1 has good biocompatibility to mouse embryonic fibroblasts (MEF), human mammary epithelial cells (MCF-10A) after 48 and 72 h of treatment using WST-1 assay. GG-BA shows great potential for the development of biomaterials such as bioadhesives, hydrogels, and coacervates.
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