Refereed review article in scientific journal (A2)

Anthocyanins as Promising Molecules Affecting Energy Homeostasis, Inflammation, and Gut Microbiota in Type 2 Diabetes with Special Reference to Impact of Acylation




List of AuthorsChen Kang, Kortesniemi Maaria Katariina, Linderborg Kaisa Marjut, Yang Baoru

PublisherAMER CHEMICAL SOC

Publication year2023

JournalJournal of Agricultural and Food Chemistry

Journal name in sourceJOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Journal acronymJ AGR FOOD CHEM

Volume number71

Issue number2

Start page1002

End page1017

Number of pages16

ISSN0021-8561

eISSN1520-5118

DOIhttp://dx.doi.org/10.1021/acs.jafc.2c05879

URLhttps://pubs.acs.org/doi/full/10.1021/acs.jafc.2c05879

Self-archived copy’s web addresshttps://research.utu.fi/converis/portal/detail/Publication/178466163


Abstract
Anthocyanins, the red-orange to blue-violet colorants present in fruits, vegetables, and tubers, have antidiabetic properties expressed via modulating energy metabolism, inflammation, and gut microbiota. Acylation of the glycosyl moieties of anthocyanins alters the physicochemical properties of anthocyanins and improves their stability. Thus, acylated anthocyanins with probiotic-like property and lower bioavailability are likely to have different biological effects from nonacylated anthocyanins on diabetes. This work highlights recent findings on the antidiabetic effects of acylated anthocyanins from the perspectives of energy metabolism, inflammation, and gut microbiota compared to the nonacylated anthocyanins and particularly emphasizes the cellular and molecular mechanisms associated with the beneficial effects of these bioactive molecules, providing a new perspective to explore the different biological effects induced by structurally different anthocyanins. Acylated anthocyanins may have greater modulating effects on energy metabolism, inflammation, and gut microbiota in type 2 diabetes compared to nonacylated anthocyanins.

Downloadable publication

This is an electronic reprint of the original article.
This reprint may differ from the original in pagination and typographic detail. Please cite the original version.




Last updated on 2023-09-02 at 09:22