Refereed review article in scientific journal (A2)

Maternal Vitamin D Levels during Pregnancy and Offspring Psychiatric Outcomes: A Systematic Review




List of Authors: Upadhyaya Subina, Ståhlberg Tiia, Silwal Sanju, Arrhenius Bianca, Sourander Andre

Publisher: MDPI

Publication year: 2022

Journal: International Journal of Molecular Sciences

Volume number: 24

Issue number: 1

DOI: http://dx.doi.org/10.3390/ijms24010063

URL: https://www.mdpi.com/1422-0067/24/1/63

Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/177945289


Abstract

Prenatal exposure to vitamin D may play a significant role in human brain development and function. Previous epidemiological studies investigating the associations between maternal vitamin D status and offspring developmental and psychiatric outcomes in humans have been inconclusive. We aimed to systematically assess the results of previously published studies that examined the associations between maternal vitamin D levels, measured as circulating 25(OH)D levels in pregnancy or at birth, and offspring neuropsychiatric and psychiatric outcomes. Systematic searches were conducted using MEDLINE, Embase, PsychINFO and Web of Science for studies published by 10 August 2022. We included human observational studies that examined associations between prenatal or perinatal vitamin D levels and offspring neuropsychiatric and psychiatric outcomes and were published in English in peer-reviewed journals. Of the 3729 studies identified, 66 studies were screened for full texts and 29 studies published between 2003 and 2022 were included in the final review. There was a small amount of evidence for the association between prenatal vitamin D deficiency and autism spectrum disorder. When studies with larger sample sizes and stricter definitions of vitamin D deficiency were considered, positive associations were also found for attention-deficit/hyperactivity disorder and schizophrenia. Future studies with larger sample sizes, longer follow-up periods and prenatal vitamin D assessed at multiple time points are needed.


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Last updated on 2023-24-01 at 15:24