A2 Refereed review article in a scientific journal
Evolving imaging methods of prostate cancer and the emergence of magnetic resonance imaging guided ablation techniques
Authors: Anttinen Mikael, Sequeiros Roberto Blanco, Boström Peter J, Taimen Pekka
Publisher: Frontiers Media SA
Publication year: 2022
Journal: Frontiers in Oncology
Journal name in source: FRONTIERS IN ONCOLOGY
Journal acronym: FRONT ONCOL
Article number: 1043688
Volume: 12
Number of pages: 11
ISSN: 2234-943X
eISSN: 2234-943X
DOI: https://doi.org/10.3389/fonc.2022.1043688
Web address : https://www.frontiersin.org/articles/10.3389/fonc.2022.1043688/full
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/177939304
Established therapies for prostate cancer (PCa), surgery and radiotherapy, treat the entire gland regardless of the location of the cancerous lesion within the prostate. Although effective, these methods include a significant risk of worsening genitourinary outcomes. Targeted image-guided cancer therapy has gained acceptance through improved PCa detection, localization, and characterization by magnetic resonance imaging (MRI). Minimally-invasive ablative techniques aim to achieve comparable oncological outcomes to radical treatment while preserving genitourinary function. Transurethral ultrasound ablation (TULSA) and next-generation transrectal high-intensity focused ultrasound (HIFU) utilize MRI guidance to thermally ablate prostate tissue under real-time MRI monitoring and active temperature feedback control. Previous trials performed by our group and others, including a large multicenter study in men with localized favorable-risk disease, have demonstrated that TULSA provides effective prostate ablation with a favorable safety profile and low impact on quality of life. Recently, MRI-guided HIFU focal therapy was also shown as a safe and effective treatment of intermediate-risk PCa. Here we review the current literature on ablative techniques in the treatment of localized PCa with a focus on TULSA and HIFU methods.
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