A1 Refereed original research article in a scientific journal
Methylation status of VTRNA2-1/nc886 is stable across populations, monozygotic twin pairs and in majority of tissues
Authors: Marttila Saara, Tamminen Hely, Rajić Sonja, Mishra Pashupati P, Lehtimäki Terho, Raitakari Olli, Kähönen Mika, Kananen Laura, Jylhävä Juulia, Hägg Sara, Delerue Thomas, Peters Annette, Waldenberger Melanie, Kleber Marcus E, März Winfried, Luoto Riitta, Raitanen Jani, Sillanpää Elina, Laakkonen Eija K, Heikkinen Aino, Ollikainen Miina, Raitoharju Emma
Publisher: FUTURE MEDICINE LTD
Publication year: 2022
Journal: Epigenomics
Journal name in source: EPIGENOMICS
Journal acronym: EPIGENOMICS-UK
Volume: 14
Issue: 18
First page : 1105
Last page: 1124
Number of pages: 20
ISSN: 1750-1911
DOI: https://doi.org/10.2217/epi-2022-0228
Web address : https://doi.org/10.2217/epi-2022-0228
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/176894046
Aims & methods: The aim of this study was to characterize the methylation level of a polymorphically imprinted gene, VTRNA2-1/nc886, in human populations and somatic tissues.48 datasets, consisting of more than 30 tissues and >30,000 individuals, were used.
Results: nc886 methylation status is associated with twin status and ethnic background, but the variation between populations is limited. Monozygotic twin pairs present concordant methylation, whereas similar to 30% of dizygotic twin pairs present discordant methylation in the nc886 locus. The methylation levels of nc886 are uniform across somatic tissues, except in cerebellum and skeletal muscle.
Conclusion: The nc886 imprint may be established in the oocyte, and, after implantation, the methylation status is stable, excluding a few specific tissues.Tweetable abstract Methylation status of a polymorphically imprinted gene, VTRNA2-1/nc886, is stable in human populations (48 cohorts, n > 30,000) and in somatic tissues, except in cerebellum and skeletal muscle. Twin data suggest it may already be established in the oocyte.
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