A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Test-retest reliability of diffusion tensor imaging scalars in 5-year-olds
Tekijät: Rosberg Aylin, Tuulari Jetro J, Kumpulainen Venla, Lukkarinen Minna, Pulli Elmo P, Silver Eero, Copeland Anni, Saukko Ekaterina, Saunavaara Jani, Lewis John D, Karlsson Linnea, Karlsson Hasse, Merisaari Harri
Kustantaja: WILEY
Julkaisuvuosi: 2022
Journal: Human Brain Mapping
Tietokannassa oleva lehden nimi: HUMAN BRAIN MAPPING
Lehden akronyymi: HUM BRAIN MAPP
Vuosikerta: 43
Numero: 16
Aloitussivu: 4984
Lopetussivu: 4994
Sivujen määrä: 11
ISSN: 1065-9471
eISSN: 1097-0193
DOI: https://doi.org/10.1002/hbm.26064
Verkko-osoite: http://dx.doi.org/10.1002%2Fhbm.26064
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/176586914
Diffusion tensor imaging (DTI) has provided great insights into the microstructural features of the developing brain. However, DTI images are prone to several artifacts and the reliability of DTI scalars is of paramount importance for interpreting and generalizing the findings of DTI studies, especially in the younger population. In this study, we investigated the intrascan test-retest repeatability of four DTI scalars: fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) in 5-year-old children (N = 67) with two different data preprocessing approaches: a volume censoring pipeline and an outlier replacement pipeline. We applied a region of interest (ROI) and a voxelwise analysis after careful quality control, tensor fitting and tract-based spatial statistics. The data had three subsets and each subset included 31, 32, or 33 directions thus a total of 96 unique uniformly distributed diffusion encoding directions per subject. The repeatability of DTI scalars was evaluated with intraclass correlation coefficient (ICC(3,1)) and the variability between test and retest subsets. The results of both pipelines yielded good to excellent (ICC(3,1) > 0.75) reliability for most of the ROIs and an overall low variability (<10%). In the voxelwise analysis, FA and RD had higher ICC(3,1) values compared to AD and MD and the variability remained low (<12%) across all scalars. Our results suggest high intrascan repeatability in pediatric DTI and lend confidence to the use of the data in future cross-sectional and longitudinal studies.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
