A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Diagnostic Accuracy of F-18-FDG-PET/CT and F-18-FDG-PET/MRI in Detecting Locoregional Recurrence of HNSCC 12 Weeks after the End of Chemoradiotherapy: Single-Center Experience with PET/MRI
Tekijät: Murtojärvi Sarita, Malaspina Simona, Kinnunen Ilpo, Tuokkola Terhi, Honka Miikka-Juhani, Saunavaara Virva, Tolvanen Tuula, Schrey Aleksi, Kemppainen Jukka
Kustantaja: WILEY-HINDAWI
Julkaisuvuosi: 2022
Journal: Contrast Media and Molecular Imaging
Tietokannassa oleva lehden nimi: CONTRAST MEDIA & MOLECULAR IMAGING
Lehden akronyymi: CONTRAST MEDIA MOL I
Artikkelin numero: 8676787
Vuosikerta: 2022
Sivujen määrä: 13
ISSN: 1555-4309
eISSN: 1555-4317
DOI: https://doi.org/10.1155/2022/8676787
Verkko-osoite: https://www.hindawi.com/journals/cmmi/2022/8676787/
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/176565945
Purpose
In head and neck squamous cell carcinoma (HNSCC), the early diagnosis and efficient detection of recurrences and/or residual tumor after treatment play a very important role in patient's prognosis. Positron emission tomography (PET) using 2-deoxy-2-F-18-fluoro-D-glucose (F-18-FDG) has become an established method for the diagnosis of suspected recurrence in head and neck carcinomas. In particular, integrated PET/MRI imaging that provides optimal soft tissue contrast and less dental implant artifacts compared to PET/CT is an intriguing technique for the follow-up imaging of HNSCC patients. The aim of this study was to evaluate the benefit of PET/MRI compared to PET/CT in post-treatment follow-up imaging of HNSCC patients.
Methods
This retrospective observational cohort study consists of 104 patients from our center with histologically confirmed HNSCC. All patients received chemoradiotherapy (CRT) and underwent F-18-FDG-PET/CT (n=52) or F-18-FDG-PET/MRI (n=52) scan 12 weeks after the end of treatment. Image analysis was performed by two independent readers according to a five-point Likert scale analysis.
Results
PET/MRI was more sensitive (1.00 vs. 0.77) than PET/CT in the detection of locoregional recurrence. PET/MRI also had better negative (1.00 vs. 0.87) predictive values. AUCs for PET/MRI and PET/CT on patient-based analysis were 0.997 (95% CI 0.989-1.000) and 0.890 (95% CI 0.806-0.974), respectively. The comparison of sensitivity, AUCs, and negative predictive values revealed a statistically significant difference, p<0.05. In PET/CT, false-negative and positive findings were observed in the more advanced disease stages, where PET/MRI performed better. Also, false-negative findings were located in the oropharyngeal, laryngeal, and nasopharyngeal regions, where PET/MRI made no false-negative interpretations.
Conclusion
Based on these results, PET/MRI might be considered the modality of choice in detecting locoregional recurrence in HNSCC patients, especially in the more advanced stages in the oral cavity, larynx, or nasopharynx.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
