A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Borrelia burgdorferi specific serum and cerebrospinal fluid antibodies in Lyme neuroborreliosis
Tekijät: Pietikäinen Annukka, Glader Otto, Kortela Elisa, Kanerva Mari, Oksi Jarmo, Hytönen Jukka
Kustantaja: ELSEVIER SCIENCE INC
Julkaisuvuosi: 2022
Journal: Diagnostic Microbiology and Infectious Disease
Tietokannassa oleva lehden nimi: DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
Lehden akronyymi: DIAGN MICR INFEC DIS
Artikkelin numero: 115782
Vuosikerta: 104
Numero: 3
Sivujen määrä: 8
ISSN: 0732-8893
eISSN: 1879-0070
DOI: https://doi.org/10.1016/j.diagmicrobio.2022.115782
Verkko-osoite: https://doi.org/10.1016/j.diagmicrobio.2022.115782
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/176383320
We used definite Lyme neuroborreliosis (LNB) adult patient acute and convalescent phase serum (n = 63 and 61, respectively) and cerebrospinal fluid (CSF; acute n = 63,3 weeks timepoint n = 41) samples to characterize Borrelia burgdorferi specific antibody responses in patient subgroups categorized by demographics, infection manifestation and phase, infecting B. burgdorferi genospecies, received antibiotic treatments, and treatment outcome. B. burgdorferi antibodies were analyzed using 4 different assays incorporating a large array of antigens. We observed that B. burgdorferi specific serum antibodies show a universal, antigen independent declining trend after antibiotic treatment of LNB at 1 year. Antibodies declined similarly among women and men over time, and the decline was independent of patient age. The antibody responses were independent of the predominant LNB manifestation, treatment received by the patient, infecting B. burgdorferi genospecies, or the subjective improvement experienced by the patients. Finally, the antibody specificities in CSF reflected the specificities observed in serum samples.
Ladattava julkaisu This is an electronic reprint of the original article. |