A1 Refereed original research article in a scientific journal
Predicting the Need for Biopsy to Detect Clinically Significant Prostate Cancer in Patients with a Magnetic Resonance Imaging–detected Prostate Imaging Reporting and Data System/Likert ≥3 Lesion: Development and Multinational External Validation of the Imperial Rapid Access to Prostate Imaging and Diagnosis Risk Score
Authors: Peters Max, Eldred-Evans David, Kurver Piet, Falagario Ugo Giovanni, Connor Martin J., Shah Taimur T., Verhoeff Joost J.C., Taimen Pekka, Aronen Hannu J., Knaapila Juha, Montoya Perez Ileana, Ettala Otto, Stabile Armando, Gandaglia Giorgio, Fossati Nicola, Martini Alberto, Cucchiara Vito, Briganti Alberto, Lantz Anna, Picker Wolfgang, Haug Erik Skaaheim, Nordström Tobias, Tanaka Mariana Bertoncelli, Reddy Deepika, Bass Edward, van Rossum Peter S.N., Wong Kathie, Tam Henry, Winkler Mathias, Gordon Stephen, Qazi Hasan, Boström Peter J., Jambor Ivan, Ahmed Hashim U.
Publisher: Elsevier B.V.
Publication year: 2022
Journal: European Urology
Journal name in source: European Urology
Volume: 82
Issue: 5
First page : 559
Last page: 568
eISSN: 1873-7560
DOI: https://doi.org/10.1016/j.eururo.2022.07.022
Web address : https://doi.org/10.1016/j.eururo.2022.07.022
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/176376695
Background: Although multiparametric magnetic resonance imaging (MRI) has high
sensitivity, its lower specificity leads to a high prevalence of false-positive lesions requir-
ing biopsy.
Objective: To develop and externally validate a scoring system for MRI-detected Prostate
Imaging Reporting and Data System (PIRADS)/Likert 3 lesions containing clinically sig-
nificant prostate cancer (csPCa).
Design, setting, and participants: The multicentre Rapid Access to Prostate Imaging and
Diagnosis (RAPID) pathway included 1189 patients referred to urology due to elevated
age-specific prostate-specific antigen (PSA) and/or abnormal digital rectal examination (DRE); April 27, 2017 to October 25, 2019.
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