A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Brown fat triglyceride content is associated with cardiovascular risk markers in adults from a tropical region
Tekijät: Monfort-Pires Milena, Regeni-Silva Giulianna, Dadson Prince, Nogueira Guilherme A, U-Din Mueez, Ferreira Sandra RG, Sapienza Marcelo Tatut, Virtanen Kirsi A, Velloso Licio A
Kustantaja: FRONTIERS MEDIA SA
Julkaisuvuosi: 2022
Journal: Frontiers in Endocrinology
Tietokannassa oleva lehden nimi: FRONTIERS IN ENDOCRINOLOGY
Lehden akronyymi: FRONT ENDOCRINOL
Artikkelin numero: 919588
Vuosikerta: 13
Sivujen määrä: 13
ISSN: 1664-2392
DOI: https://doi.org/10.3389/fendo.2022.919588
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/176264709
Brown adipose tissue (BAT) is regarded as an interesting potential target for the treatment of obesity, diabetes, and cardiovascular diseases, and the detailed characterization of its structural and functional phenotype could enable an advance in these fields. Most studies evaluating BAT structure and function were performed in temperate climate regions, and we are yet to know how these findings apply to the 40% of the world's population living in tropical areas. Here, we used F-18-fluorodeoxyglucose positron emission tomography - magnetic resonance imaging to evaluate BAT in 45 lean, overweight, and obese volunteers living in a tropical area in Southeast Brazil. We aimed at investigating the associations between BAT activity, volume, metabolic activity, and BAT content of triglycerides with adiposity and cardiovascular risk markers in a sample of adults living in a tropical area and we showed that BAT glucose uptake is not correlated with leanness; instead, BAT triglyceride content is correlated with visceral adiposity and markers of cardiovascular risk. This study expands knowledge regarding the structure and function of BAT in people living in tropical areas. In addition, we provide evidence that BAT triglyceride content could be an interesting marker of cardiovascular risk.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
