A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Respiratory Syncytial Virus-Associated Hospital Admissions and Bed Days in Children <5 Years of Age in 7 European Countries
Tekijät: Wang Xin, Li You, Fernandez Liliana Vazquez, Teirlinck Anne C, Lehtonen Toni, van Wijhe Maarten, Stona Luca, Bangert Mathieu, Reeves Rachel M, Bøås Håkon, van Boven Michiel, Heikkinen Terho, Johannesen Caroline Klint, Baraldi Eugenio, Dona Donà, Tong Sabine, Campbell Harry; Respiratory Syncytial Virus Consortium in Europe (RESCEU) Investigators
Kustantaja: OXFORD UNIV PRESS INC
Julkaisuvuosi: 2022
Journal: Journal of Infectious Diseases
Tietokannassa oleva lehden nimi: JOURNAL OF INFECTIOUS DISEASES
Lehden akronyymi: J INFECT DIS
Vuosikerta: 226
Numero: Suppl. 1
Aloitussivu: S22
Lopetussivu: S28
Sivujen määrä: 7
ISSN: 0022-1899
eISSN: 1537-6613
DOI: https://doi.org/10.1093/infdis/jiab560
Verkko-osoite: https://academic.oup.com/jid/article/226/Supplement_1/S22/6505262?login=true
Background
Respiratory syncytial virus (RSV) is a leading cause of respiratory tract infections (RTIs) in young children. High-quality country-specific estimates of bed days and length of stay (LOS) show the population burden of RSV-RTI on secondary care services and the burden among patients, and can be used to inform RSV immunization implementation decisions.Methods
We estimated the hospital burden of RSV-associated RTI (RSV-RTI) in children under 5 years in 7 European countries (Finland, Denmark, Norway, Scotland, England, the Netherlands, and Italy) using routinely collected hospital databases during 2001-2018. We described RSV-RTI admission rates during the first year of life by birth month and assessed their correlation with RSV seasonality in 5 of the countries (except for England and Italy). We estimated average annual numbers and rates of bed days for RSV-RTI and other-pathogen RTI, as well as the hospital LOS.
Results
We found that infants born 2 months before the peak month of RSV epidemics more frequently had the highest RSV-RTI hospital admission rate. RSV-RTI hospital episodes accounted for 9.9-21.2 bed days per 1000 children aged <5 years annually, with the median (interquartile range) LOS ranging from 2 days (0.5-4 days) to 4 days (2-6 days) between countries. Between 70% and 89% of these bed days were in infants aged <1 year, representing 40.3 (95% confidence interval [CI], 40.1-40.4) to 91.2 (95% CI, 90.6-91.8) bed days per 1000 infants annually. The number of bed days for RSV-RTI was higher than that for RTIs associated with other pathogens in infants aged <1 year, especially in those
Conclusions
RSV disease prevention therapies (monoclonal antibodies and maternal vaccines) for infants could help prevent a substantial number of bed days due to RSV-RTI. "High-risk" birth months should be considered when developing RSV immunization schedules. Variation in LOS between countries might reflect differences in hospital care practices.