A2 Refereed review article in a scientific journal
Lifestyle, metabolic disorders and male hypogonadism - A one-way ticket?
Authors: Crisostomo L, Pereira SC, Monteiro MP, Raposo JF, Oliveira PF, Alves MG
Publisher: ELSEVIER IRELAND LTD
Publication year: 2020
Journal: Molecular and Cellular Endocrinology
Journal name in source: MOLECULAR AND CELLULAR ENDOCRINOLOGY
Journal acronym: MOL CELL ENDOCRINOL
Article number: 110945
Volume: 516
Number of pages: 10
ISSN: 0303-7207
DOI: https://doi.org/10.1016/j.mce.2020.110945(external)
Web address : https://www.sciencedirect.com/science/article/pii/S0303720720302458(external)
Hypogonadism is more frequent among men with common metabolic diseases, notably obesity and type 2 diabetes. Indeed, endocrine disruption caused by metabolic diseases can trigger the onset of hypogonadism, although the underlying molecular mechanisms are not entirely understood. Metabolic diseases are closely related to unhealthy lifestyle choices, such as dietary habits and sedentarism. Therefore, hypogonadism is part of a pathological triad gathering unhealthy lifestyle, metabolic disease and genetic background. Additionally, hypogonadism harbors the potential to aggravate underlying metabolic disorders, further sustaining the mechanisms leading to disease. To what extent does lifestyle intervention in men suffering from these metabolic disorders can prevent, improve or reverse hypogonadism, is still controversial. Moreover, recent evidence suggests that the metabolic status of the father is related to the risk of inter and transgenerational inheritance of hypogonadism. In this review, we will address the proposed mechanisms of disease, as well as currently available interventions for hypogonadism.
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