A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Prognostic value of P-wave morphology in general population
Tekijät: Laitinen Idamaria, Kenttä Tuomas V, Passi Jussi, Haukilahti Mira Anette E, Eranti Antti, Holkeri Arttu, Aro Aapo L, Kerola Tuomas, Noponen Kai, Seppänen Tapio, Rissanen Harri, Knekt Paul, Heliövaara Markku, Ukkola Olavi H, Junttila M Juhani, Huikuri Heikki V, Perkiömäki Juha S
Kustantaja: OXFORD UNIV PRESS
Julkaisuvuosi: 2022
Lehti: EP-Europace
Tietokannassa oleva lehden nimi: EUROPACE
Lehden akronyymi: EUROPACE
Artikkelin numero: euac121
Sivujen määrä: 11
ISSN: 1099-5129
DOI: https://doi.org/10.1093/europace/euac121
Julkaisun avoimuus kirjaamishetkellä: Ei avoimesti saatavilla
Julkaisukanavan avoimuus : Osittain avoin julkaisukanava
Verkko-osoite: https://doi.org/10.1093/europace/euac121
Aims: To evaluate the prognostic significance of novel P-wave morphology descriptors in general population.
Methods and results: Novel P-wave morphology variables were analyzed from orthogonal X-, Y-, Z-leads of the digitized electrocardiogram using a custom-made software in 6906 middle-aged subjects of the Mini-Finland Health Survey. A total of 3747 (54.3%) participants died during the follow-up period of 24.3 ± 10.4 years; 379 (5.5%) of the study population succumbed to sudden cardiac death (SCD), 928 (13.4%) to non-SCD (NSCD) and 2440 (35.3%) patients to non-cardiac death (NCD). In univariate comparisons, most of the studied P-wave morphology parameters had a significant association with all modes of death (P from <0.05 to <0.001). After relevant adjustments in the Cox multivariate hazards model, P-wave morphology dispersion (PMD) still tended to predict SCD [hazard ratio (HR): 1.006, 95% confidence interval (CI): 1.000-1.012, P = 0.05) but not NSCD (HR: 0.999, 95% CI: 0.995-1.003, P = 0.68) or NCD (HR: 0.999, 95% CI: 0.997-1.001, P = 0.44). The P-wave maximum amplitude in the lead Z (P-MaxAmp-Z) predicted SCD even after multivariate adjustments (HR: 1.010, 95% CI: 1.005-1.015, P = 0.0002) but also NSCD (HR: 1.005, 95% CI: 1.002-1.009, P = 0.0005) and NCD (HR: 1.002, 95% CI: 1.000-1.005, P = 0.03).
Conclusion: Abnormalities of P-wave morphology are associated with the risk of all modes of death in general population. After relevant adjustments, PMD was still closely associated with the risk of SCD but not with NSCD or NCD. P-MaxAmp-Z predicted SCD even after adjustments, however, it also retained its association with NSCD and NCD.
