A1 Refereed original research article in a scientific journal

Trajectories of adolescent psychotic-like experiences and early cannabis exposure: Results from a Finnish Birth Cohort Study




AuthorsDenissoff Alexander, Mustonen Antti, Miettunen Jouko, Alakokkare Anni E, Veijola Juha, Scott James G, Sami Musa B, Niemelä Solja

PublisherELSEVIER

Publication year2022

JournalSchizophrenia Research

Journal name in sourceSCHIZOPHRENIA RESEARCH

Journal acronymSCHIZOPHR RES

Volume246

First page 95

Last page102

Number of pages8

ISSN0920-9964

DOIhttps://doi.org/10.1016/j.schres.2022.06.014

Web address https://doi.org/10.1016/j.schres.2022.06.014

Self-archived copy’s web addresshttps://research.utu.fi/converis/portal/detail/Publication/176000293


Abstract

Background: Longitudinal studies examining the effect of cannabis exposure (CE) on the prognosis of adolescents with psychotic-like experiences (PLEs) are scarce. We examined trajectories of mental health in adolescents with PLEs and cannabis exposure.

Methods: The Northern Finland Birth Cohort 1986 (n = 6552) with linkage to nationwide register data was used. Information on lifetime cannabis exposure was collected when participants were aged 15/16. Register-based outcome data on diagnoses made in clinical practice were obtained until age 33. Logistic regression was used to study the association of PLE/CE patterns and subsequent psychiatric disorders. The group with neither PLEs nor CE was utilized as the reference group. Parental psychiatric disorders, family structure, sex, frequent alcohol intoxications, daily smoking and illicit substance use other than cannabis were adjusted for.

Results: In all, 6552 subjects (49.2 % males) were included in analysis. PLEs with cannabis exposure were associated with any psychiatric disorder (OR = 2.59; 95 % CI 1.82-3.68), psychotic disorders (OR = 3.86; 95 % CI 1.83-8.11), mood disorders (OR 4.07; 95 % CI 2.74-6.04), depressive disorders (OR = 4.35; 95 % CI 2.93-6.48), anxiety disorders (OR = 2.06; 95 % CI 1.34-3.17) and substance use disorders (OR = 2.26; 95 % CI 1.13-4.50) compared to reference group. Effect sizes were greater for group with both PLEs and cannabis use than for group with PLEs only.

Conclusions: Early-onset cannabis use is an adverse prognostic marker for adolescents with PLEs after extensive confounder control including other substance use.


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