A1 Refereed original research article in a scientific journal
NIV-NAVA versus NCPAP immediately after birth in premature infants: A randomized controlled trial
Authors: Lee Juyoung, Parikka Vilhelmiina, Oda Arata, Wallström Linda, Lehtonen Liisa, Soukka Hanna
Publisher: ELSEVIER
Publication year: 2022
Journal: Respiratory Physiology and Neurobiology
Journal name in source: RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
Journal acronym: RESP PHYSIOL NEUROBI
Article number: 103916
Volume: 302
Number of pages: 6
ISSN: 1569-9048
eISSN: 1878-1519
DOI: https://doi.org/10.1016/j.resp.2022.103916
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/175500871
Objective: To evaluate whether noninvasive-neurally adjusted ventilatory assist (NIV-NAVA) decrease respiratory efforts compared to nasal continuous positive airway pressure (NCPAP) during the first hours of life.
Methods: Twenty infants born between 28+0 and 31+6 weeks were randomized to NIV-NAVA or NCPAP. Positive end-expiratory pressure was constantly kept at 6 cmH(2)O for both groups and the NAVA level was 1.0 cmH(2)O/mu V for NIV-NAVA group. The electrical activity of diaphragm (Edi) were recorded for the first two hours.
Results: Peak and minimum Edi decreased similarly in both groups (P = 0.98 and P = 0.59, respectively). Leakages were higher in the NIV-NAVA group than in the NCPAP group (P < 0.001). The neural apnea defined as a flat Edi for >= 5 s were less frequent in NIV-NAVA group than in NCPAP group (P = 0.046).
Conclusions: Immediately applied NIV-NAVA in premature infants did not reduce breathing effort, measured as peak Edi. However, NIV-NAVA decreased neural apneic episodes compared to NCPAP.
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