A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Optoretinogram: optical measurement of human cone and rod photoreceptor responses to light
Tekijät: Azimipour M, Valente D, Vienola KV, Werner JS, Zawadzki RJ, Jonnal RS
Kustantaja: Optica
Julkaisuvuosi: 2020
Journal: Optics Letters
Tietokannassa oleva lehden nimi: OPTICS LETTERS
Lehden akronyymi: Opt. Lett.
Vuosikerta: 45
Numero: 17
Aloitussivu: 4658
Lopetussivu: 4661
Sivujen määrä: 4
ISSN: 0146-9592
DOI: https://doi.org/10.1364/OL.398868
Verkko-osoite: https://opg.optica.org/ol/fulltext.cfm?uri=ol-45-17-4658&id=434516
Tiivistelmä
Noninvasive, objective measurement of rod function is as significant as that of cone function, and for retinal diseases such as retinitis pigmentosa and age-related macular degeneration, rod function may be a more sensitive biomarker of disease progression and efficacy of treatment than cone function. Functional imaging of single human rod photoreceptors, however, has proven difficult because their small size and rapid functional response pose challenges for the resolution and speed of the imaging system. Here, we describe light-evoked, functional responses of human rods and cones, measured noninvasively using a synchronized. adaptive optics optical coherence tomography (OCT) and. scann ing light ophthalmoscopy (SW) system. The higher lateral resolution of the SW images made it possible to confirm the identity of rods in the corresponding OCT volumes. (C) 2020 Optical Society of America
Noninvasive, objective measurement of rod function is as significant as that of cone function, and for retinal diseases such as retinitis pigmentosa and age-related macular degeneration, rod function may be a more sensitive biomarker of disease progression and efficacy of treatment than cone function. Functional imaging of single human rod photoreceptors, however, has proven difficult because their small size and rapid functional response pose challenges for the resolution and speed of the imaging system. Here, we describe light-evoked, functional responses of human rods and cones, measured noninvasively using a synchronized. adaptive optics optical coherence tomography (OCT) and. scann ing light ophthalmoscopy (SW) system. The higher lateral resolution of the SW images made it possible to confirm the identity of rods in the corresponding OCT volumes. (C) 2020 Optical Society of America
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