Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1)
Kilohertz retinal FF-SS-OCT and flood imaging with hardware-based adaptive optics
Julkaisun tekijät: Valente D, Vienola KV, Zawadzki RJ, Jonnal RS
Kustantaja: Optica
Julkaisuvuosi: 2020
Journal: Biomedical Optics Express
Tietokannassa oleva lehden nimi: BIOMEDICAL OPTICS EXPRESS
Lehden akronyymi: Biomed. Opt. Express
Volyymi: 11
Julkaisunumero: 10
Aloitussivu: 5995
Lopetussivun numero: 6011
Sivujen määrä: 17
ISSN: 2156-7085
DOI: http://dx.doi.org/10.1364/BOE.403509
Verkko-osoite: https://opg.optica.org/boe/fulltext.cfm?uri=boe-11-10-5995&id=440174
Tiivistelmä
A retinal imaging system was designed for full-field (FF) swept-source (SS) optical coherence tomography (OCT) with cellular resolution. The system incorporates a real-time adaptive optics (AO) subsystem and a very high-speed CMOS sensor, and is capable of acquiring volumetric images of the retina at rates up to 1 kHz. While digital aberration correction (DAC) is an attractive potential alternative to AO, it has not yet been shown to provide resolution allowing visualization of cones in the fovea, where early detection of functional deficits is most critical. Here we demonstrate that FF-SS-OCT with hardware AO permits resolution of foveal cones, imaged at eccentricities of 1 degrees and 2 degrees, with volume rates adequate to measure light-evoked changes in photoreceptors. With the reference arm blocked, the system can operate as a kilohertz AO flood illumination fundus camera with adjustable temporal coherence and is expected to allow measurement of light-evoked changes caused by common path interference in photoreceptor outer segments (OS). In this paper, we describe the system's optical design, characterize its performance, and demonstrate its ability to produce images of the human photoreceptor mosaic. (C) 2020 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
A retinal imaging system was designed for full-field (FF) swept-source (SS) optical coherence tomography (OCT) with cellular resolution. The system incorporates a real-time adaptive optics (AO) subsystem and a very high-speed CMOS sensor, and is capable of acquiring volumetric images of the retina at rates up to 1 kHz. While digital aberration correction (DAC) is an attractive potential alternative to AO, it has not yet been shown to provide resolution allowing visualization of cones in the fovea, where early detection of functional deficits is most critical. Here we demonstrate that FF-SS-OCT with hardware AO permits resolution of foveal cones, imaged at eccentricities of 1 degrees and 2 degrees, with volume rates adequate to measure light-evoked changes in photoreceptors. With the reference arm blocked, the system can operate as a kilohertz AO flood illumination fundus camera with adjustable temporal coherence and is expected to allow measurement of light-evoked changes caused by common path interference in photoreceptor outer segments (OS). In this paper, we describe the system's optical design, characterize its performance, and demonstrate its ability to produce images of the human photoreceptor mosaic. (C) 2020 Optical Society of America under the terms of the OSA Open Access Publishing Agreement