A1 Refereed original research article in a scientific journal
A Data-Driven Clustering Method for Discovering Profiles in the Dynamics of Major Depressive Disorder Using a Smartphone-Based Ecological Momentary Assessment of Mood
Authors: van Genugten Claire R, Schuurmans Josien, Hoogendoorn Adriaan W, Araya Ricardo, Andersson Gerhard, Banos Rosa M, Berger Thomas, Botella Cristina, Pashoja Arlinda Cerga, Cieslak Roman, Ebert David D, Garcia-Palacios Azucena, Hazo Jean-Baptiste, Herrero Rocío, Holtzmann Jérôme, Kemmeren Lise, Kleiboer Annet, Krieger Tobias, Rogala Anna, Titzler Ingrid, Topooco Naira, Smit Johannes H, Riper Heleen
Publisher: Frontiers Media SA
Publication year: 2022
Journal: Frontiers in Psychiatry
Journal name in source: FRONTIERS IN PSYCHIATRY
Journal acronym: FRONT PSYCHIATRY
Article number: 755809
Volume: 13
Number of pages: 12
ISSN: 1664-0640
DOI: https://doi.org/10.3389/fpsyt.2022.755809(external)
Web address : https://doi.org/10.3389/fpsyt.2022.755809(external)
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/175332747(external)
Background
Although major depressive disorder (MDD) is characterized by a pervasive negative mood, research indicates that the mood of depressed patients is rarely entirely stagnant. It is often dynamic, distinguished by highs and lows, and it is highly responsive to external and internal regulatory processes. Mood dynamics can be defined as a combination of mood variability (the magnitude of the mood changes) and emotional inertia (the speed of mood shifts). The purpose of this study is to explore various distinctive profiles in real-time monitored mood dynamics among MDD patients in routine mental healthcare.
Methods
Ecological momentary assessment (EMA) data were collected as part of the cross-European E-COMPARED trial, in which approximately half of the patients were randomly assigned to receive the blended Cognitive Behavioral Therapy (bCBT). In this study a subsample of the bCBT group was included (n = 287). As part of bCBT, patients were prompted to rate their current mood (on a 1-10 scale) using a smartphone-based EMA application. During the first week of treatment, the patients were prompted to rate their mood on three separate occasions during the day. Latent profile analyses were subsequently applied to identify distinct profiles based on average mood, mood variability, and emotional inertia across the monitoring period.
Results
Overall, four profiles were identified, which we labeled as: (1) "very negative and least variable mood" (n = 14) (2) "negative and moderate variable mood" (n = 204), (3) "positive and moderate variable mood" (n = 41), and (4) "negative and highest variable mood" (n = 28). The degree of emotional inertia was virtually identical across the profiles.
Conclusions
The real-time monitoring conducted in the present study provides some preliminary indications of different patterns of both average mood and mood variability among MDD patients in treatment in mental health settings. Such varying patterns were not found for emotional inertia.
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