A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Global spatial dynamics and vaccine-induced fitness changes of Bordetella pertussis
Tekijät: Lefrancq Noémie, Bouchez Valérie, Fernandes Nadia, Barkoff Alex-Mikael, Bosch Thijs, Dalby Tine, Åkerlund Thomas, Darenberg Jessica, Fabianova Katerina, Vestrheim Didrik F., Fry Norman K., González-López Juan Jose, Gullsby Karolina, Habington Adele, He Qiushui, Litt David, Martini Helena, Piérard Denis, Stefanelli Paola, Stegger Marc, Zavadilova Jana, Armatys Nathalie, Landier Annie, Guillot Sophie, Hong Samuel L., Lemey Philippe, Parkhill Julian, Toubiana Julie, Cauchemez Simopn, Salje Henrik, Brisse Sylvain
Kustantaja: AAAS
Julkaisuvuosi: 2022
Journal: Science Translational Medicine
Tietokannassa oleva lehden nimi: Science translational medicine
Artikkelin numero: eabn3253
Vuosikerta: 14
Numero: 642
eISSN: 1946-6242
DOI: https://doi.org/10.1126/scitranslmed.abn3253
Verkko-osoite: https://www.science.org/doi/10.1126/scitranslmed.abn3253
Rinnakkaistallenteen osoite: https://www.repository.cam.ac.uk/handle/1810/335039
As with other pathogens, competitive interactions between Bordetella pertussis strains drive infection risk. Vaccines are thought to perturb strain diversity through shifts in immune pressures; however, this has rarely been measured because of inadequate data and analytical tools. We used 3344 sequences from 23 countries to show that, on average, there are 28.1 transmission chains circulating within a subnational region, with the number of chains strongly associated with host population size. It took 5 to 10 years for B. pertussis to be homogeneously distributed throughout Europe, with the same time frame required for the United States. Increased fitness of pertactin-deficient strains after implementation of acellular vaccines, but reduced fitness otherwise, can explain long-term genotype dynamics. These findings highlight the role of vaccine policy in shifting local diversity of a pathogen that is responsible for 160,000 deaths annually.