A1 Refereed original research article in a scientific journal
Coronary volume to left ventricular mass ratio in patients with diabetes mellitus
Authors: Kuneman Jurrien H, Mahdiui Mohammed El, Rosendael Alexander R Van, van den Hoogen Inje J, Patel Manesh R, Nørgaard Bjarne Linde, Fairbairn Timothy A, Koen Nieman, Takashi Akasaka, Berman Daniel S, Hurwitz Lynne M. Koweek, Pontone Gianluca, Kawasaki Tomohiro, Rønnow Niels Peter, Sand Jesper M, Jensen,Amano, Tetsuya Poon Michael, Øvrehus Kristian A, Sonck Jeroen, Rabbat Mark G, De Bruyne Bernand, Campbell Rogers, Matsuo Hitoshi, Bax Jeroen J, Leipsic Jonathon A., Knuuti Juhani
Publisher: Elsevier
Publication year: 2022
Journal: Journal of Cardiovascular Computed Tomography
Volume: 16
Issue: 4
First page : 319
Last page: 326
DOI: https://doi.org/10.1016/j.jcct.2022.01.004
Web address : https://doi.org/10.1016/j.jcct.2022.01.004
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/175167962
Background
Diabetes mellitus is a major risk factor for coronary artery disease (CAD) and may provoke structural and functional changes in coronary vasculature. The coronary volume to left ventricular mass (V/M) ratio is a new anatomical parameter capable of revealing a potential physiological imbalance between coronary vasculature and myocardial mass. The aim of this study was to examine the V/M derived from coronary computed tomography angiography (CCTA) in patients with diabetes.
Methods
Patients with clinically suspected CAD enrolled in the ADVANCE (Assessing Diagnostic Value of Non-invasive FFRCT in Coronary Care) registry and known diabetic status were included. Coronary artery volume and left ventricular myocardial mass were analyzed from CCTA and the V/M ratio was calculated and compared between patients with and without diabetes.
Results
Of the 3053 patients (age 66 ± 10 years; 66% male) with known diabetic status, diabetes was present in 21.9%. Coronary volume was lower in patients with diabetes compared to those without diabetes (2850 ± 940 mm3 vs. 3040 ± 970 mm3, p < 0.0001), whereas the myocardial mass was comparable between the 2 groups (122 ± 33 g vs. 122 ± 32 g, p = 0.70). The V/M ratio was significantly lower in patients with diabetes (23.9 ± 6.8 mm3/g vs. 25.7 ± 7.5 mm3/g, p < 0.0001). Among subjects with obstructive CAD (n = 2191, 24.0% diabetics) and non-obstructive CAD (16.7% diabetics), the V/M ratio was significantly lower in patients with diabetes compared to those without (23.4 ± 6.7 mm3/g vs. 25.0 ± 7.3 mm3/g, p < 0.0001 and 25.6 ± 6.9 mm3/g vs. 27.3 ± 7.6 mm3/g, respectively, p = 0.006).
Conclusion
The V/M ratio was significantly lower in patients with diabetes compared to non-diabetics, even after correcting for obstructive coronary stenosis. The clinical value of the reduced V/M ratio in diabetic patients needs further investigation.
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