A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Atrial Fibrillation and Adverse Outcomes in Patients Undergoing Simultaneous Pancreas-Kidney Transplantation
Tekijät: Hellman Tapio, Ahopelto Kaisa, Räihä Juulia, Järvisalo Mikko J., Lempinen Marko, Helanterä Iikka
Kustantaja: Elsevier
Julkaisuvuosi: 2022
Journal: Transplantation Proceedings
Tietokannassa oleva lehden nimi: Transplantation Proceedings
eISSN: 1873-2623
DOI: https://doi.org/10.1016/j.transproceed.2021.11.042(external)
Verkko-osoite: https://www.sciencedirect.com/science/article/pii/S0041134522001038#!(external)
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/175035390(external)
Background
There are no published data on atrial fibrillation (AF) in patients receiving simultaneous pancreas-kidney transplantation (SPKT). We explored the epidemiology and adverse outcomes of AF in SPKT recipients in this retrospective observational cohort study.
Materials and Methods
All 200 SPKT recipients in Finland to date between March 2010 and April 2021 were included in the present study. Demographics, comorbidities, medications, and transplantation data were collected from the electronic patient records. Outcome measures included new-onset AF (NOAF), ischemic stroke, and death.
Results
Median age was 42 years (interquartile range [IQR] 35-49), 69 (35%) were female, and median dialysis vintage was 13 months (IQR 9-19). Altogether 7 patients (4%) had a previous diagnosis of AF at baseline, and heart failure was independently associated with prior AF in the age-adjusted multivariable logistic regression analysis. After a median follow-up of 3 years (IQR 1-5), 2 patients (1%) were observed with incident NOAF, 4 (2%) with ischemic stroke, and 7 patients (4%) died. Prior AF or NOAF were not associated with cardiovascular adverse outcomes, mortality or graft outcomes.
Conclusions
We demonstrate a low prevalence and incidence of AF for the first time in this large observational study comprising all SPKT recipients in Finland to date.
Ladattava julkaisu This is an electronic reprint of the original article. |